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KMID : 0363619970180010456
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Journal of Korean Oriental Medicine
1997 Volume.18 No. 1 p.456 ~ p.469
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The Effect of Sohabhyangwon(蘇合香元) on Regional Cerebral Blood Flow and Area of Cerebral Infarction in the Experimentally induced Cerebral Infarction in Rats
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Choi Eun-Jeong
Lee Won-Chul
Shin Gil-Cho
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Abstract
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The cerebral infarction arised from occulsion of cerebral artery has a high mortality rate and fatal sequelae. Sohabhyangwon(蘇合香元) is generally regarded to have a effect of walking up the patient from unconsiousness and promoting the flow of Qj(氣) by warming channel.
Metood :The purpose of this study is to find out the effections of Sohabhyangwon(蘇合香元) on regional cerebral blood flow and relative cerebral infarction area in the experimentally induced infartion in rats In this experiment, 12 Spraque-Dawley rats weighting 280-350g were used. Cerebral ischemia induced by intraluminal suture technique of Kozumi’’s and Zea-Longer’’s method. Co_{2},;O_2, pH, arterial blood pressure in rats were checked by Blood Gas Analyzer every 30 minutes for 2 hours. And regional cerebral blood flow were checking by hydrogen clearance technique, cerebral infarcted area was megsured by Image Analysis System.
Results :1. During the experiment, CO_{2},;O_2, pH, arterial blood pressure in rats had no change in both sample group and control group. 2. Cortical cerebral blood flow decreased at same rate in both sample group and control group after inducing cerebral infarction. 3. On comparison of relative cerebral infarcted area, Sohabhyangwon(蘇合香元) perfused group showed a significant decrease.
Conclusion :According to the result above, Sohabhyangwon has a protection effect on cranial nerve and-has no effect on cerebral blood flow.
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KEYWORD
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Sohabhyangwon, Cerebral blood flow, Relative infarcted area
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